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Fumio Nakagawa Selected Research

Trifluridine (Viroptic)

12/2016Effect of a novel oral chemotherapeutic agent containing a combination of trifluridine, tipiracil and the novel triple angiokinase inhibitor nintedanib, on human colorectal cancer xenografts.
9/2015Efficacy of Combination Chemotherapy Using a Novel Oral Chemotherapeutic Agent, TAS-102, with Oxaliplatin on Human Colorectal and Gastric Cancer Xenografts.
8/2015Exposure-dependent incorporation of trifluridine into DNA of tumors and white blood cells in tumor-bearing mouse.
5/2015Efficacy of combination chemotherapy using a novel oral chemotherapeutic agent, TAS-102, together with bevacizumab, cetuximab, or panitumumab on human colorectal cancer xenografts.
2/2004Thymidine kinase and thymidine phosphorylase level as the main predictive parameter for sensitivity to TAS-102 in a mouse model.

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Fumio Nakagawa Research Topics

Disease

27Neoplasms (Cancer)
04/2021 - 01/2002
16Colorectal Neoplasms (Colorectal Cancer)
09/2018 - 04/2004
6Stomach Neoplasms (Stomach Cancer)
07/2021 - 03/2015
6Breast Neoplasms (Breast Cancer)
06/2020 - 01/2002
5Neoplasm Metastasis (Metastasis)
07/2018 - 01/2002
5Colonic Neoplasms (Colon Cancer)
07/2012 - 05/2009
4Body Weight (Weight, Body)
01/2017 - 05/2009
2Brain Neoplasms (Brain Tumor)
04/2021 - 07/2018
2Body Weight Changes
08/2015 - 05/2012
1Lung Neoplasms (Lung Cancer)
01/2020
1Multiple Myeloma
12/2019
1Ataxia Telangiectasia (Louis Bar Syndrome)
07/2019
1Sarcoma (Soft Tissue Sarcoma)
07/2019
1Encephalitis (Encephalitis, Rasmussen)
05/2019
1Vasculitis (Vasculitides)
05/2019
1Weight Loss (Weight Reduction)
01/2019
1Cicatrix (Scar)
07/2018
1Hematoma
07/2018
1Hemangiosarcoma (Angiosarcoma)
07/2018
1Hemorrhage
07/2018
1Abscess
07/2018
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
05/2012
1Head and Neck Neoplasms (Head and Neck Cancer)
11/2010

Drug/Important Bio-Agent (IBA)

17Fluorouracil (Carac)FDA LinkGeneric
03/2018 - 01/2002
13trifluridine tipiracil drug combinationIBA
07/2021 - 02/2004
7EnzymesIBA
12/2019 - 01/2002
6Pharmaceutical PreparationsIBA
06/2020 - 02/2004
6Leucovorin (Folinic Acid)FDA Link
01/2018 - 03/2007
6DNA (Deoxyribonucleic Acid)IBA
12/2016 - 02/2004
5Paclitaxel (Taxol)FDA LinkGeneric
07/2018 - 01/2002
5Thymidylate SynthaseIBA
03/2018 - 01/2002
5Trifluridine (Viroptic)FDA LinkGeneric
12/2016 - 02/2004
5Thymidine PhosphorylaseIBA
09/2015 - 05/2003
4Oxaliplatin (Eloxatin)FDA LinkGeneric
01/2018 - 10/2010
4Proteins (Proteins, Gene)FDA Link
07/2011 - 07/2002
4Messenger RNA (mRNA)IBA
07/2011 - 07/2002
4Folic Acid (Vitamin M)FDA LinkGeneric
05/2011 - 03/2007
4ProdrugsIBA
11/2010 - 12/2004
3NucleosidesIBA
09/2015 - 07/2002
3Capecitabine (Xeloda)FDA Link
07/2012 - 12/2004
3TegafurIBA
11/2010 - 07/2005
3Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)IBA
07/2005 - 01/2002
2AntibodiesIBA
06/2020 - 05/2012
2Tyrosine Kinase InhibitorsIBA
01/2020 - 05/2012
2TAS4464IBA
12/2019 - 01/2019
2UbiquitinIBA
12/2019 - 01/2019
2tipiracilIBA
09/2015 - 05/2015
2Antineoplastic Agents (Antineoplastics)IBA
09/2015 - 05/2015
2Bevacizumab (Avastin)FDA Link
05/2015 - 05/2012
2Cetuximab (Erbitux)FDA Link
05/2015 - 05/2012
2Irinotecan (Camptosar)FDA LinkGeneric
03/2015 - 10/2010
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
05/2012 - 05/2003
2UracilIBA
11/2010 - 07/2005
2gimeracilIBA
11/2010 - 10/2010
2doxifluridineIBA
07/2005 - 01/2002
2Taxoids (Taxanes)IBA
12/2004 - 01/2002
1pertuzumabIBA
06/2020
1TAS0728IBA
06/2020
1Ado-Trastuzumab EmtansineIBA
06/2020
1Immunoconjugates (Immunoconjugate)IBA
06/2020
1Trastuzumab (Herceptin)FDA Link
06/2020
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
06/2020
1TAS-116IBA
01/2020
1Proteasome Endopeptidase Complex (Proteasome)IBA
12/2019
1TrabectedinIBA
07/2019
1A-Form DNA (A-DNA)IBA
07/2019
1Protein Kinases (Protein Kinase)IBA
07/2019
1SteroidsIBA
05/2019
1Ligases (Synthetase)IBA
01/2019
1Cullin Proteins (Cullins)IBA
01/2019
1regorafenibIBA
09/2018
1Monoclonal AntibodiesIBA
01/2017
1nintedanibIBA
12/2016
1Drug CombinationsIBA
12/2016
1Panitumumab (Vectibix)FDA Link
05/2015
1Erlotinib Hydrochloride (CP 358,774)FDA Link
05/2012
1Sorafenib (BAY 43-9006)FDA Link
05/2012
1Sunitinib (Sutent)FDA Link
05/2012
1Aromatase InhibitorsIBA
07/2011
1Complementary DNA (cDNA)IBA
07/2011
1Estrogen ReceptorsIBA
07/2011
1Doxorubicin (Adriamycin)FDA LinkGeneric
07/2011
1Estrogens (Estrogen)FDA Link
07/2011
1Anastrozole (Arimidex)FDA LinkGeneric
07/2011
1Aromatase (CYP19)IBA
07/2011
1folylpolyglutamate synthetaseIBA
05/2011
1Small Interfering RNA (siRNA)IBA
05/2011
1Staphylococcal Protein A (Protein A)IBA
11/2010

Therapy/Procedure

19Therapeutics
06/2020 - 04/2004
5Drug Therapy (Chemotherapy)
09/2018 - 11/2010
4Combination Drug Therapy (Combination Chemotherapy)
09/2015 - 07/2012
2Aftercare (After-Treatment)
01/2017 - 07/2011
1Endoscopes
04/2021
1Anesthesia
04/2021
1Punctures
04/2021
1Craniotomy
07/2018
1Thoracoplasty
07/2018
1Oral Administration
08/2015
1Chemoradiotherapy
11/2010
1Radiotherapy
11/2010